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Heterocyclic Hemipiperazines: Multistimuli‐responsive Switches and Sensors for Zinc or Cadmium Ions

Schäfer, Valentin 1; Pianowski, Zbigniew 1,2
1 Institut für Organische Chemie (IOC), Karlsruher Institut für Technologie (KIT)
2 Institut für Biologische und Chemische Systeme (IBCS), Karlsruher Institut für Technologie (KIT)

Abstract:

Advance in the design of molecular photoswitches - adapters that convert light into changes at molecular level – opens up exciting possibilities in preparing smart polymers, drugs photoactivated inside humans, or light-fueled nanomachines that might in the future operate in our bloodstream. Hemipiperazines are recently reported biocompatible molecular photoswitches based on cyclic dipeptides. Here we report a multistimuli-responsive hemipiperazine-based switch that reacts on light, solvents, acidity, or metal ions. Its photoequilibration is controlled by the intramolecular hydrogen bonding pattern. The compound can be used as a mid-nanomolar photoswitchable fluorescent sensor for zinc and cadmium ions, applicable to monitor environmental pollution in real time.


Zugehörige Institution(en) am KIT Institut für Biologische und Chemische Systeme (IBCS)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2024
Sprache Englisch
Identifikator ISSN: 0947-6539, 1521-3765
KITopen-ID: 1000173336
Erschienen in Chemistry – A European Journal
Verlag John Wiley and Sons
Vorab online veröffentlicht am 03.09.2024
Nachgewiesen in Web of Science
Dimensions
Scopus
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