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Indole Derivatives: A Versatile Scaffold in Modern Drug Discovery—An Updated Review on Their Multifaceted Therapeutic Applications (2020–2024)

Mo, Xingyou; Rao, Devendra Pratap; Kaur, Kirandeep; Hassan, Roket; Abdel-Samea, Ahmed S.; Farhan, Sara Mahmoud; Bräse, Stefan 1; Hashem, Hamada
1 Institut für Biologische und Chemische Systeme (IBCS), Karlsruher Institut für Technologie (KIT)

Abstract:

Indole derivatives have become an important class of compounds in medicinal chemistry, recognized for their wide-ranging biological activities and therapeutic potential. This review provides a comprehensive overview of recent advances in the evaluation of indole-based compounds in the last five years, highlighting their roles in cancer treatment, infectious disease management, anti-inflammatory therapies, metabolic disorder interventions, and neurodegenerative disease management. Indole derivatives have shown significant efficacy in targeting diverse biological pathways, making them valuable scaffolds in designing new drugs. Notably, these compounds have demonstrated the ability to combat drug-resistant cancer cells and pathogens, a significant breakthrough in the field, and offer promising therapeutic options for chronic diseases such as diabetes and hypertension. By summarizing recent key findings and exploring the underlying biological mechanisms, this review underscores the potential of indole derivatives in addressing major healthcare challenges, thereby instilling hope and optimism in the field of modern medicine.


Verlagsausgabe §
DOI: 10.5445/IR/1000176450
Veröffentlicht am 20.11.2024
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Biologische und Chemische Systeme (IBCS)
Publikationstyp Zeitschriftenaufsatz
Publikationsmonat/-jahr 10.2024
Sprache Englisch
Identifikator ISSN: 1420-3049
KITopen-ID: 1000176450
Erschienen in Molecules
Verlag MDPI
Band 29
Heft 19
Seiten 4770
Vorab online veröffentlicht am 09.10.2024
Schlagwörter indole, biological activities, anticancer, antimicrobial, anti-inflammatory, antidiabetic, neurodegenerative diseases, antihypertensive
Nachgewiesen in Scopus
Web of Science
Dimensions
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