Synthesis, enzyme inhibition, and docking studies of new schiff bases of disalicylic acid methylene-based derivatives as dual-target antibacterial agents
Al-Wahaibi, Lamya H.; Mahmoud, Mohamed A.; Alzahrani, Hayat Ali; Abou-Zied, Hesham A.; Abdelmoez, Alshaimaa; Youssif, Bahaa G. M. ; Bräse, Stefan
1; Rabea, Safwat M.
1 Institut für Biologische und Chemische Systeme (IBCS), Karlsruher Institut für Technologie (KIT)
1; Rabea, Safwat M.1 Institut für Biologische und Chemische Systeme (IBCS), Karlsruher Institut für Technologie (KIT)
Abstract:
Bacteria have acquired resistance to almost all antibiotics currently in use due to their extensive, broad, and improper utilization over a prolonged period. DNA gyrase and DHFR exhibit significant promise as targets for antibacterial therapeutics.
| Zugehörige Institution(en) am KIT | Institut für Biologische und Chemische Systeme (IBCS) |
| Publikationstyp | Zeitschriftenaufsatz |
| Publikationsdatum | 12.11.2024 |
| Sprache | Englisch |
| Identifikator | ISSN: 2296-2646 KITopen-ID: 1000178315 |
| HGF-Programm | 43.33.11 (POF IV, LK 01) Adaptive and Bioinstructive Materials Systems |
| Erschienen in | Frontiers in Chemistry |
| Verlag | Frontiers Media SA |
| Band | 12 |
| Seiten | Art.-Nr.: 1493906 |
| Nachgewiesen in | OpenAlex Scopus Web of Science Dimensions |
| Globale Ziele für nachhaltige Entwicklung |