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A stratified treatment algorithm in psychiatry: a program on stratified pharmacogenomics in severe mental illness (Psych-STRATA): concept, objectives and methodologies of a multidisciplinary project funded by Horizon Europe

Baune, B. T. ; Fromme, S. E.; Aberg, M.; Adli, M.; Afantitis, A.; Akkouh, I.; Andreassen, O. A.; Angulo, C.; Barlati, S.; Brasso, C.; Bucci, P.; Budde, M.; Buspavanich, P.; Cavone, V.; Demyttenaere, K.; Diaz-Caneja, C. M.; Dierssen, M.; Djurovic, S.; Driessen, M.; ... mehr

Abstract:

Schizophrenia (SCZ), bipolar (BD) and major depression disorder (MDD) are severe psychiatric disorders that are challenging to treat, often leading to treatment resistance (TR). It is crucial to develop effective methods to identify and treat patients at risk of TR at an early stage in a personalized manner, considering their biological basis, their clinical and psychosocial characteristics. Effective translation of theoretical knowledge into clinical practice is essential for achieving this goal. The Psych-STRATA consortium addresses this research gap through a seven-step approach. First, transdiagnostic biosignatures of SCZ, BD and MDD are identified by GWAS and multi-modal omics signatures associated with treatment outcome and TR (steps 1 and 2). In a next step (step 3), a randomized controlled intervention study is conducted to test the efficacy and safety of an early intensified pharmacological treatment. Following this RCT, a combined clinical and omics-based algorithm will be developed to estimate the risk for TR. This algorithm-based tool will be designed for early detection and management of TR (step 4). This algorithm will then be implemented into a framework of shared treatment decision-making with a novel mental health board (step 5). ... mehr

Zugehörige Institution(en) am KIT Institut für Sport und Sportwissenschaft (IfSS)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2024
Sprache Englisch
Identifikator ISSN: 0940-1334, 0003-9373, 0175-758X, 1433-8491
KITopen-ID: 1000178492
Erschienen in European Archives of Psychiatry and Clinical Neuroscience
Verlag Springer
Vorab online veröffentlicht am 27.12.2024
Nachgewiesen in Scopus
Web of Science
Dimensions

Verlagsausgabe §
DOI: 10.5445/IR/1000178492
Veröffentlicht am 28.01.2025
Seitenaufrufe: 13
seit 28.01.2025
Downloads: 8
seit 29.01.2025
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