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An insight into the therapeutic impact of quinoxaline derivatives: Recent advances in biological activities (2020–2024)

Waseem, Aly M.; Elmagzoub, Ranya Mohammed; Abdelgadir, Mervat Mohammed Mazhar; Bahir, Areej Al; EL-Gawaad, N. S. Abd; Abdel-Samea, Ahmed S.; Rao, Devendra Pratap ; Kossenas, Konstantinos; Bräse, Stefan 1; Hashem, Hamada
1 Institut für Biologische und Chemische Systeme (IBCS), Karlsruher Institut für Technologie (KIT)

Abstract:

Quinoxaline derivatives have garnered significant attention due to their wide-ranging therapeutic applications. Research from 2020 to 2024 has demonstrated their potent bioactivity across various domains, including anticancer, antimicrobial, antiviral, anti-inflammatory, and antidiabetic activities. Structural modifications guided by structure–activity relationship (SAR) studies have enabled the development of targeted quinoxaline-based compounds with enhanced efficacy. These derivatives interact with critical biological targets such as enzymes, receptors, and signaling pathways, offering promising avenues for treating complex diseases like cancer and infectious diseases. Advanced studies, including molecular docking and ADMET analyses, have further clarified their pharmacological profiles, optimizing their drug-like properties and bioavailability. This review provides a comprehensive overview of the recent advancements in quinoxaline-based therapies, underscoring their potential impact on modern drug discovery and therapeutic applications.

Zugehörige Institution(en) am KIT Institut für Biologische und Chemische Systeme (IBCS)
Publikationstyp Zeitschriftenaufsatz
Publikationsmonat/-jahr 01.2025
Sprache Englisch
Identifikator ISSN: 2211-7156
KITopen-ID: 1000178503
Erschienen in Results in Chemistry
Verlag Elsevier
Band 13
Seiten 101989
Nachgewiesen in Scopus
Dimensions

Verlagsausgabe §
DOI: 10.5445/IR/1000178503
Veröffentlicht am 30.01.2025
Originalveröffentlichung
DOI: 10.1016/j.rechem.2024.101989
Scopus
Zitationen: 1
Dimensions
Zitationen: 1
Seitenaufrufe: 20
seit 30.01.2025
Downloads: 7
seit 02.02.2025
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