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Physical fitness and incident mild cognitive impairment: a systematic review

Bergmann, Matteo 1; Geda, Yonas E.; Bös, Klaus 1; Woll, Alexander ORCID iD icon 1; Krell-Rösch, Janina ORCID iD icon 1
1 Institut für Sport und Sportwissenschaft (IfSS), Karlsruher Institut für Technologie (KIT)

Abstract:

Background
Higher physical fitness is associated with various health outcomes, including decreased dementia risk. Little is known as to whether physical fitness is also associated with new onset of mild cognitive impairment (MCI). Our aim was to provide an overview of longitudinal research on the associations between physical fitness and the risk of incident MCI.

Methods
We conducted a systematic literature review that examined associations between different components of physical fitness such as strength or endurance with incident MCI in older adults. We searched PubMed, Scopus, and Web of Science databases for longitudinal and/ or prospective cohort studies published in English or German. Screening was performed independently by two authors, and quality of included studies was assessed using the Newcastle Ottawa Scale.

Results
The search yielded 12,298 studies, of which 19 were included in the review, with follow-up times ranging from 2 to 26 years, and sample sizes ranging from 87 to 995,243 persons. Thirteen studies that examined associations between strength, variables related to muscle quality and function with incident MCI revealed inconsistent findings, e.g., six studies showed that lower handgrip strength was associated with higher MCI risk or that higher handgrip strength was associated with decreased MCI risk, respectively; while five studies reported no associations between handgrip strength and MCI risk or only for females. ... mehr


Verlagsausgabe §
DOI: 10.5445/IR/1000182377
Veröffentlicht am 16.06.2025
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Sport und Sportwissenschaft (IfSS)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2025
Sprache Englisch
Identifikator ISSN: 1813-7253, 1861-6909
KITopen-ID: 1000182377
Erschienen in European review of aging and physical activity
Verlag Springer Fachmedien Wiesbaden
Band 22
Seiten Article no: 10
Vorab online veröffentlicht am 14.06.2025
Nachgewiesen in Web of Science
OpenAlex
Dimensions
Scopus
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