Coherence locking in a parallel nuclear magnetic resonance probe defends against gradient field spillover
He, Mengjia 1; MacKinnon, Neil
1; Buyens, Dominique 1; Luy, Burkhard
2,3; Korvink, Jan G. 1
1 Institut für Mikrostrukturtechnik (IMT), Karlsruher Institut für Technologie (KIT)
2 Institut für Biologische Grenzflächen (IBG), Karlsruher Institut für Technologie (KIT)
3 Institut für Organische Chemie (IOC), Karlsruher Institut für Technologie (KIT)
1; Buyens, Dominique 1; Luy, Burkhard
2,3; Korvink, Jan G. 11 Institut für Mikrostrukturtechnik (IMT), Karlsruher Institut für Technologie (KIT)
2 Institut für Biologische Grenzflächen (IBG), Karlsruher Institut für Technologie (KIT)
3 Institut für Organische Chemie (IOC), Karlsruher Institut für Technologie (KIT)
Abstract:
The implementation of parallel nuclear magnetic resonance detection aims to enhance measurement
throughput in support of high-throughput-screening applications, including, for example, drug discovery. In sup-
port of modern pulse sequences and solvent suppression methods, each detection site must have independent
pulsed field gradient capabilities. Hereby, a challenge is introduced in which the local gradients applied in par-
allel detectors introduce field spillover into adjacent channels, leading to spin dephasing and, hence, to signal
suppression. This study proposes a compensation scheme employing optimized pulses to achieve coherence
locking during gradient pulse periods. The design of coherence-locking pulses utilizes optimal control to ad-
dress gradient-induced field inhomogeneity. These pulses are applied in a pulsed-gradient spin echo (PGSE)
experiment and a parallel heteronuclear single quantum coherence (HSQC) experiment, demonstrating their ef-
fectiveness in protecting the desired coherences from gradient field spillover. This compensation scheme presents
a valuable solution for magnetic resonance probes equipped with parallel and independently switchable gradient
... mehr
throughput in support of high-throughput-screening applications, including, for example, drug discovery. In sup-
port of modern pulse sequences and solvent suppression methods, each detection site must have independent
pulsed field gradient capabilities. Hereby, a challenge is introduced in which the local gradients applied in par-
allel detectors introduce field spillover into adjacent channels, leading to spin dephasing and, hence, to signal
suppression. This study proposes a compensation scheme employing optimized pulses to achieve coherence
locking during gradient pulse periods. The design of coherence-locking pulses utilizes optimal control to ad-
dress gradient-induced field inhomogeneity. These pulses are applied in a pulsed-gradient spin echo (PGSE)
experiment and a parallel heteronuclear single quantum coherence (HSQC) experiment, demonstrating their ef-
fectiveness in protecting the desired coherences from gradient field spillover. This compensation scheme presents
a valuable solution for magnetic resonance probes equipped with parallel and independently switchable gradient
... mehr
| Zugehörige Institution(en) am KIT | Institut für Biologische Grenzflächen (IBG) Institut für Mikrostrukturtechnik (IMT) Institut für Organische Chemie (IOC) |
| Publikationstyp | Zeitschriftenaufsatz |
| Publikationsjahr | 2025 |
| Sprache | Englisch |
| Identifikator | ISSN: 2699-0016 KITopen-ID: 1000183352 |
| HGF-Programm | 43.35.02 (POF IV, LK 01) Functionality of Soft Matter and Biomolecular Systems |
| Erschienen in | Magnetic Resonance |
| Verlag | Copernicus Publications |
| Band | 6 |
| Heft | 2 |
| Seiten | 173–181 |
| Projektinformation | SFB 1527; HyPERiON, 454252029 (DFG, DFG KOORD, SFB 1527_1) |
| Vorab online veröffentlicht am | 17.07.2025 |
| Nachgewiesen in | OpenAlex Scopus Dimensions |