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Mild Behavioral Impairment: A Population-Based Study

Vassilaki, Maria ; Syrjanen, Jeremy A.; Krell-Rösch, Janina ORCID iD icon 1; Graff-Radford, Jonathan; Vemuri, Prashanthi; Fields, Julie A.; Kremers, Walter K.; Jack Jr., Clifford R.; Knopman, David S.; Lyketsos, Constantine G.; Petersen, Ronald C.; Geda, Yonas E.
1 Institut für Sport und Sportwissenschaft (IfSS), Karlsruher Institut für Technologie (KIT)

Abstract:

Objective:
The authors conducted a population-based investigation of mild behavioral impairment (MBI) in the Mayo Clinic Study of Aging setting. MBI refers to new onset of neuropsychiatric symptoms (NPS) among adults ages ≥50 that is not due to a psychiatric disorder and that may be a precursor of cognitive decline or dementia.

Methods:
The Neuropsychiatric Inventory Questionnaire was used in a cross-sectional study of participants ≥50 years without dementia to assess for NPS. Linear and logistic regression models were estimated and adjusted for age, sex, and education.

Results:
The study sample comprised 2,713 participants (mean±SD age=74.6±9.5 years, 47% women). Overall, 11% of the participants had MBI at the first follow-up; 2,498 were cognitively unimpaired (10% of whom had MBI), and 215 had mild cognitive impairment (MCI; 29% of whom had MBI). Having MBI was associated with significantly higher odds of MCI (OR=3.47, 95% CI=2.46–4.84) and lower cognitive scores. Severe MBI was associated with even higher MCI odds (OR=5.15, 95% CI=2.73–9.37) and lower cognitive scores.

Conclusions:
In this study of older adults, participants with MCI were almost three times more likely than cognitively unimpaired participants to have MBI. ... mehr


Originalveröffentlichung
DOI: 10.1176/appi.neuropsych.20240155
Zugehörige Institution(en) am KIT Institut für Sport und Sportwissenschaft (IfSS)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2025
Sprache Englisch
Identifikator ISSN: 0895-0172, 1545-7222
KITopen-ID: 1000184314
Erschienen in The journal of neuropsychiatry and clinical neurosciences
Verlag American Psychiatric Publishing
Vorab online veröffentlicht am 26.08.2025
Nachgewiesen in OpenAlex
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