KIT | KIT-Bibliothek | Impressum | Datenschutz

The SFB/TRR 393 Collaborative Research Centre: trajectories of affective disorders – Cognitive–emotional mechanisms of symptom change = Sonderforschungsbereich SFB/TRR 393: Verlaufsformen affektiver Erkrankungen – Kognitiv-emotionale Mechanismen von Symptomveränderungen

SFB/TRR 393 consortium; Kircher, Tilo ; Alexander, Nina; Bauer, Michael; Dannlowski, Udo; Ebner-Priemer, Ulrich Walter 1; Kanske, Philipp; Wöhr, Markus; Pfennig, Andrea; Alferink, Judith; Bernhardt, Nadine; Culmsee, Carsten; Ehrlich, Stefan
1 Institut für Sport und Sportwissenschaft (IfSS), Karlsruher Institut für Technologie (KIT)

Abstract:

Major depressive disorder (MDD) and bipolar disorder (BD) are prevalent and disabling psychiatric disorders, often following a chronic and relapsing course. The Collaborative Research Centre 393 (SFB/TRR 393), funded by the German Research Foundation (DFG), aims to identify trajectories and symptom changes in MDD and BD, with a focus on cognitive–emotional mechanisms and their neurobiological underpinnings.

Our research initiative seeks to (1) identify individual trajectories of recurrences and remissions in affective disorder (AD), (2) determine cognitive–emotional mechanisms and neurobiological correlates of acute symptom changes, and (3) probe mechanism-based interventions.

These goals will be pursued through a threefold approach: (1) Continuous mobile assessment in a prospective cohort: We will combine in-depth clinical characterization with multilevel neuroimaging, biobanking, and -omics analyses in 1500 AD patients and healthy participants over a 2-year follow-up (German Mental Health Cohort, GEMCO) at three time points. Participants will be drawn from existing DFG FOR 2107 and BMBF Early-BipoLife cohorts (Domain A). (2) Identification of key cognitive-emotional mechanisms: We will study emotion regulation, expectation, social cognition, and cognitive–behavioural rhythms, and their neurobiological correlates mediating symptom changes, using parallel human studies and animal experiments (Domain B). ... mehr


Verlagsausgabe §
DOI: 10.5445/IR/1000186696
Veröffentlicht am 11.11.2025
Originalveröffentlichung
DOI: 10.1007/s00115-025-01886-8
Scopus
Zitationen: 2
Web of Science
Zitationen: 1
Dimensions
Zitationen: 2
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Sport und Sportwissenschaft (IfSS)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2025
Sprache Englisch
Identifikator ISSN: 0028-2804, 1433-0407
KITopen-ID: 1000186696
Erschienen in Der Nervenarzt
Verlag Springer
Vorab online veröffentlicht am 12.09.2025
Nachgewiesen in Web of Science
Dimensions
Scopus
OpenAlex
KIT – Die Universität in der Helmholtz-Gemeinschaft
KITopen Landing Page