Time Restricted Eating in Alzheimer’s Disease: TREAD
Geda, Yonas Endale ; Rivera, DeJarra; Krell-Roesch, Janina
1; Zaniletti, Isabella; Chahal, Geetika; Smith, Tracy; DeCuna, Candice; Hettiwatte, Yehansa; Aliskevich, Emily; Gunning, Jordan; Demeke, Migbare; Khan, Nevine; Eagan, Danielle; Racette, Susan
1 Institut für Sport und Sportwissenschaft (IfSS), Karlsruher Institut für Technologie (KIT)
1; Zaniletti, Isabella; Chahal, Geetika; Smith, Tracy; DeCuna, Candice; Hettiwatte, Yehansa; Aliskevich, Emily; Gunning, Jordan; Demeke, Migbare; Khan, Nevine; Eagan, Danielle; Racette, Susan1 Institut für Sport und Sportwissenschaft (IfSS), Karlsruher Institut für Technologie (KIT)
Abstract:
Background
Time Restricted Eating (TRE) may impact cognition favorably. TRE leads to a metabolic switch from glucose to fatty acid and ketone utilization, leading to a cascade of adaptive metabolic and cellular responses. Cortical glucose uptake is decreased in Alzheimer’s disease (AD), however, ketone uptake is preserved. Little is known about the impact of TRE in patients with mild cognitive impairment (MCI). We sought to investigate the feasibility of implementing a TRE intervention among patients with MCI.
Method
Setting: Barrow Neurological Institute in Phoenix, USA. Design: Time Series design in which the participant serves as his/her own control with cognitive, behavioral and biomarker assessments at pre- and post-interventions. Intervention: 16 hours of fasting and an 8 hour eating window daily, on approximately 5 Days/week, for 3 months. Meal tracking was monitored by an app. Intended sample : 30 study participants that meet the Mayo Clinic Criteria for MCI, age 60-80 years old, BMI >18.5 and <40.0 kg/m2, and having a supportive study partner. Outcome measures for feasibility: participant recruitment and retention and metrics of acceptability, safety, and adherence to the intervention. ... mehr
Time Restricted Eating (TRE) may impact cognition favorably. TRE leads to a metabolic switch from glucose to fatty acid and ketone utilization, leading to a cascade of adaptive metabolic and cellular responses. Cortical glucose uptake is decreased in Alzheimer’s disease (AD), however, ketone uptake is preserved. Little is known about the impact of TRE in patients with mild cognitive impairment (MCI). We sought to investigate the feasibility of implementing a TRE intervention among patients with MCI.
Method
Setting: Barrow Neurological Institute in Phoenix, USA. Design: Time Series design in which the participant serves as his/her own control with cognitive, behavioral and biomarker assessments at pre- and post-interventions. Intervention: 16 hours of fasting and an 8 hour eating window daily, on approximately 5 Days/week, for 3 months. Meal tracking was monitored by an app. Intended sample : 30 study participants that meet the Mayo Clinic Criteria for MCI, age 60-80 years old, BMI >18.5 and <40.0 kg/m2, and having a supportive study partner. Outcome measures for feasibility: participant recruitment and retention and metrics of acceptability, safety, and adherence to the intervention. ... mehr
| Zugehörige Institution(en) am KIT | Institut für Sport und Sportwissenschaft (IfSS) |
| Publikationstyp | Zeitschriftenaufsatz |
| Publikationsmonat/-jahr | 12.2025 |
| Sprache | Englisch |
| Identifikator | ISSN: 1552-5260, 1552-5279 KITopen-ID: 1000189429 |
| Erschienen in | Alzheimer’s and Dementia |
| Verlag | John Wiley and Sons |
| Band | 21 |
| Heft | S7 |
| Seiten | Art.-Nr.: e108364 |
| Vorab online veröffentlicht am | 23.12.2025 |
| Nachgewiesen in | OpenAlex Dimensions Scopus |