Electrochemical Synthesis of 1,2-Substituted N -Amido Benzimidazoles by Reduction of Nitroarenes
Abstract:
Despite the vast number of reports on benzimidazoles, 1,2-substituted N-amido benzimidazoles remain an underrepresented and scarcely accessible compound class with promisingpharmacological relevance. We present a safe, reliable electrochemical protocol that provides easy access to those structures. The reaction exhibits broad functional group tolerance and affords the target compounds in ≤89% yields.
| Zugehörige Institution(en) am KIT | Institut für Biologische und Chemische Systeme (IBCS) |
| Publikationstyp | Zeitschriftenaufsatz |
| Publikationsdatum | 27.02.2026 |
| Sprache | Englisch |
| Identifikator | ISSN: 1523-7060, 1523-7052 KITopen-ID: 1000191297 |
| Erschienen in | Organic Letters |
| Verlag | American Chemical Society (ACS) |
| Band | 28 |
| Heft | 8 |
| Seiten | 2591 - 2595 |
| Vorab online veröffentlicht am | 16.02.2026 |
| Nachgewiesen in | Web of Science Scopus OpenAlex |