A solid-phase click$^2$ strategy for chromophore–DNA conjugates and their application as a light harvesting system
Abstract:
A stepwise and orthogonal approach of two independent click reactions directly on the solid phase gives easy access to doubly modified DNA. Firstly, 5′-ethynyl-2′-deoxyuridine reacts directly with an azide-modified porphyrin; secondly, 5′-azido-2′-deoxyuridine is generated in situ from 5′-iodo-2′-deoxyuridine, which enables a click reaction with an alkyne-functionalized pyrene. The doubly modified DNA was characterized as a light-harvesting system.
| Zugehörige Institution(en) am KIT | Institut für Organische Chemie (IOC) |
| Publikationstyp | Zeitschriftenaufsatz |
| Publikationsjahr | 2026 |
| Sprache | Englisch |
| Identifikator | ISSN: 1359-7345, 1364-548X KITopen-ID: 1000191773 |
| Erschienen in | Chemical Communications |
| Verlag | Royal Society of Chemistry (RSC) |
| Vorab online veröffentlicht am | 13.03.2026 |
| Nachgewiesen in | Web of Science OpenAlex |