Direct Electrochemical Synthesis of Tetrahydroisoquinolines through Shono-Type Oxidation
Abstract:
Direct electrochemical access to the valuable tetrahydroisoquinoline scaffold has been developed. In a simple undivided setup using inexpensive, reusable electrodes, amides are transformed via Shono-type oxidation into multisubstituted tetrahydroisoquinolines. A broad scope with 34 examples containing electron-poor and heterocyclic substrates was synthesized. Additionally, access to the benzazepine scaffold could also be realized in this way.
| Zugehörige Institution(en) am KIT | Institut für Biologische und Chemische Systeme (IBCS) |
| Publikationstyp | Zeitschriftenaufsatz |
| Publikationsjahr | 2026 |
| Sprache | Englisch |
| Identifikator | ISSN: 1523-7060, 1523-7052 KITopen-ID: 1000195270 |
| Erschienen in | Organic Letters |
| Verlag | American Chemical Society (ACS) |
| Vorab online veröffentlicht am | 07.07.2026 |
| Nachgewiesen in | OpenAlex |