An Open, Agentic GenAI Ecosystem Integrated with the European Open Science Cloud

Generative Artificial Intelligence (GenAI) is transforming research by enabling new forms of discovery, automation, and collaboration. However, current AI ecosystems often lack transparency, reproducibility, and alignment with open science principles, raising concerns about data provenance, ethical use, and reliance on proprietary platforms. The recently approved European project, EOSC-ARENA (starting in June 2026), aims to create an independent, open, and agentic GenAI ecosystem integrated with the European Open Science Cloud (EOSC), supporting researchers across the entire research data lifecycle.
Methodologically, EOSC-ARENA incorporates human-centered and responsible AI principles, with dedicated work packages focused on research integrity, ethics, and skills development. Building on the AI4EOSC platform, EOSC-ARENA will provide federated infrastructure for Federated GenAI model fine-tuning, scalable model serving, and trustworthy knowledge-augmentation services, including Retrieval-Augmented Generation and Model Context Protocols, across European e-infrastructures and EOSC Nodes. It will ensure model, data, and platform independence in line with the EU AI Act, FAIR principles, and EOSC policies.
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The project will validate its infrastructure through interdisciplinary use cases in life sciences, medical imaging and oncology, climate science, cosmology, materials science, food science, and research data management, aiming to improve data quality, FAIRness, and research productivity. A dedicated work package on research integrity, ethics, and responsible AI will develop cross-domain curricula, guidelines, and open educational resources, embedding human-centered, trustworthy, and reproducible practices into GenAI workflows.
In this contribution, we present the EOSC-ARENA project, highlighting its vision, infrastructure, and planned agentic GenAI framework.