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A blind circadian clock in cavefish reveals that opsins mediate peripheral clock photoreception

Cavallari, Nicola; Frigato, Elena; Vallone, Daniela; Fröhlich, Nadine; Lopez-Olmeda, Jose Fernande; Foa, Augusto; Berti, Roberto; Sanchez-Vazquez, Francisco Javier; Bertolluci, Christiano; Foulkes, Nicolas S.

The circadian clock is synchronized with the day-night cycle primarily by light. Fish represent fascinating models for deciphering the light input pathway to the vertebrate clock since fish cell clocks are regulated by direct light exposure. Here we have performed a comparative, functional analysis of the circadian clock involving the zebrafish that is normally exposed to the day-night cycle and a cavefish species that has evolved in perpetual darkness. Our results reveal that the cavefish retains a food-entrainable clock that oscillates with an infradian period. Importantly, however, this clock is not regulated by light. This comparative study pinpoints the two extra-retinal photoreceptors Melanopsin (Opn4m2) and TMT-opsin as essential upstream elements of the peripheral clock light input pathway.

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Volltext §
DOI: 10.5445/IR/110084013
DOI: 10.1371/journal.pbio.1001142
Zitationen: 115
Web of Science
Zitationen: 103
Seitenaufrufe: 35
seit 03.07.2018
Downloads: 31
seit 05.10.2016
Zugehörige Institution(en) am KIT Institut für Toxikologie und Genetik (ITG)
Publikationstyp Zeitschriftenaufsatz
Jahr 2011
Sprache Englisch
Identifikator ISSN: 1544-9173, 1545-7885
KITopen-ID: 110084013
HGF-Programm 47.01.01 (POF II, LK 01)
Erschienen in PLoS biology
Band 9
Heft 9
Seiten e1001142
Bemerkung zur Veröffentlichung Gefördert durch den KIT-Publikationsfonds
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