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URN: urn:nbn:de:swb:90-AAA1100840132
Originalveröffentlichung
DOI: 10.1371/journal.pbio.1001142
Scopus
Zitationen: 103
Web of Science
Zitationen: 91

A blind circadian clock in cavefish reveals that opsins mediate peripheral clock photoreception

Cavallari, Nicola; Frigato, Elena; Vallone, Daniela; Fröhlich, Nadine; Lopez-Olmeda, Jose Fernande; Foa, Augusto; Berti, Roberto; Sanchez-Vazquez, Francisco Javier; Bertolluci, Christiano; Foulkes, Nicolas S.

Abstract:
The circadian clock is synchronized with the day-night cycle primarily by light. Fish represent fascinating models for deciphering the light input pathway to the vertebrate clock since fish cell clocks are regulated by direct light exposure. Here we have performed a comparative, functional analysis of the circadian clock involving the zebrafish that is normally exposed to the day-night cycle and a cavefish species that has evolved in perpetual darkness. Our results reveal that the cavefish retains a food-entrainable clock that oscillates with an infradian period. Importantly, however, this clock is not regulated by light. This comparative study pinpoints the two extra-retinal photoreceptors Melanopsin (Opn4m2) and TMT-opsin as essential upstream elements of the peripheral clock light input pathway.


Zugehörige Institution(en) am KIT Institut für Toxikologie und Genetik (ITG)
Publikationstyp Zeitschriftenaufsatz
Jahr 2011
Sprache Englisch
Identifikator ISSN: 1544-9173, 1545-7885
KITopen ID: 110084013
HGF-Programm 47.01.01; LK 01
Erschienen in PLoS biology
Band 9
Heft 9
Seiten e1001142
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