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DOI: 10.5445/IR/110092610
Veröffentlicht am 02.05.2018
DOI: 10.3389/fncir.2013.00009
Zitationen: 44
Web of Science
Zitationen: 39

Circadian clocks, rhythmic synaptic plasticity and the sleep-wake cycle in zebrafish

Elbaz, I.; Foulkes, N.S.; Gothilf, Y.; Appelbaum, L.

The circadian clock and homeostatic processes are fundamental mechanisms that regulate sleep. Surprisingly, despite decades of research, we still do not know why we sleep. Intriguing hypotheses suggest that sleep regulates synaptic plasticity and consequently has a beneficial role in learning and memory. However, direct evidence is still limited and the molecular regulatory mechanisms remain unclear. The zebrafish provides a powerful vertebrate model system that enables simple genetic manipulation, imaging of neuronal circuits and synapses in living animals, and the monitoring of behavioral performance during day and night. Thus, the zebrafish has become an attractive model to study circadian and homeostatic processes that regulate sleep. Zebrafish clock- and sleep-related genes have been cloned, neuronal circuits that exhibit circadian rhythms of activity and synaptic plasticity have been studied, and rhythmic behavioral outputs have been characterized. Integration of this data could lead to a better understanding of sleep regulation. Here, we review the progress of circadian clock and sleep studies in zebrafish with special emphas ... mehr

Zugehörige Institution(en) am KIT Institut für Toxikologie und Genetik (ITG)
Publikationstyp Zeitschriftenaufsatz
Jahr 2013
Sprache Englisch
Identifikator ISSN: 1662-5110
URN: urn:nbn:de:swb:90-AAA1100926105
KITopen ID: 110092610
HGF-Programm 47.01.01; LK 01
Erschienen in Frontiers in neural circuits
Band 7
Seiten 9
Schlagworte zebrafish, circadian rhythms, synaptic plasticity, circadian clock, sleep, hypocretin, orexin, melatonin
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