Growth inhibitory action of distinct sequences derived from the co-chaperone Bag-1L

Bag-1L is a multifunctional protein overexpressed in prostate, breast and colon cancer among the others. In this work a region of 68 amino acids has been found to inhibit the growth of 22Rv.1 and LNCaP prostate cancer cell lines but not of the BPH-1 bening prostate cells in colony forming assay and xenograft mouse models by binding to the molecular chaperones GRP75 and GRP78. A shorter sequence of 19 amino acids has been found sufficient for binding the target proteins and inhibit growth.