Fluid Flow Simulation and Optimisation with Lattice Boltzmann Methods on High Performance Computers - Application to the Human Respiratory System

An overall strategy for numerical simulations of the full human respiratory system is introduced. The integrative approach takes advantage of numerical simulation, high performance computing and newly developed mathematical optimisation techniques, all based on a mesoscopic model description and on lattice Boltzmann methods as discretisation strategies. Validated numerical results are presented for the simulation of respirations in a real human lung and nose geometry captured by CT.