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ECG Based Analysis of the Ventricular Repolarisation in the Human Heart

Baas, Tobias

Abstract:
ECG recordings provide diagnostic relevant information on the de- and repolarisation sequences of the heart. A modification of the repolarisation sequence is assumed to cause Torsades de Pointes. Especially drug induced effects on the repolarisation processes are in focus, since some non-cardiac drugs have been associated with sudden cardiac death in the 1990s.
The analysis of the ventricular repolarisation using a set of parameters depicting the morphology of the T-wave is introduced in this work. Therefore, new methods of fully automatic patient-specific QRS detection, beat classification and precise T-wave delineation are presented. Using these methods, medical studies are investigated regarding the modification of the T-wave by different compounds. Also the impact of the heart rate on the morphology of the T-wave is part of this research.
The reliable identification of ventricular ectopic beats allows an analysis of the influence of these beats on subsequent heart beats. It turned out that the morphology of subsequent heart beats can significantly be changed. This might give new information on the proarrythmical risk of ventricular ectopic beats.

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Volltext §
DOI: 10.5445/KSP/1000028834
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Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Biomedizinische Technik (IBT)
Publikationstyp Hochschulschrift
Publikationsjahr 2012
Sprache Englisch
Identifikator ISBN: 978-3-86644-882-7
ISSN: 1864-5933
urn:nbn:de:0072-288347
KITopen-ID: 1000028834
Verlag KIT Scientific Publishing
Umfang XX, 224 S.
Serie Karlsruhe transactions on biomedical engineering / Ed.: Karlsruhe Institute of Technology / Institute of Biomedical Engineering ; 18
Art der Arbeit Dissertation
Fakultät Fakultät für Elektrotechnik und Informationstechnik (ETIT)
Institut Institut für Biomedizinische Technik (IBT)
Prüfungsdaten 09.07.2012
Referent/Betreuer Prof. O. Dössel
Schlagwörter QT interval, QT prolongation, Repolarisation, T wave, HRT
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