Optimization of chromatographic multi-component separations in silico using HTS-data
Abstract:
In this thesis critical issues concerning the application of mechanistic models for the development and optimization of chromatography processes are addressed and improved.
A central topic of the thesis is the evaluation of chances and challenges for simulation and optimization when data from standard high-throughput experimentation (HTE) is included into model calibration.
A central topic of the thesis is the evaluation of chances and challenges for simulation and optimization when data from standard high-throughput experimentation (HTE) is included into model calibration.
| Zugehörige Institution(en) am KIT | Institut für Bio- und Lebensmitteltechnik (BLT) |
| Publikationstyp | Hochschulschrift |
| Publikationsjahr | 2012 |
| Sprache | Englisch |
| Identifikator | urn:nbn:de:swb:90-305540 KITopen-ID: 1000030554 |
| Verlag | Karlsruher Institut für Technologie (KIT) |
| Art der Arbeit | Dissertation |
| Fakultät | Fakultät für Chemieingenieurwesen und Verfahrenstechnik (CIW) |
| Institut | Institut für Bio- und Lebensmitteltechnik (BLT) |
| Prüfungsdaten | 28.09.2012 |
| Schlagwörter | Chromatographie, Optimierung, High-Throughput, Fehlerfortpflanzung, Downstream processing |
| Referent/Betreuer | Hubbuch, J. |