High-Throughput Atomistic Modeling of Biomolecular Structure and Association

The reliability of many protein models arising from structure prediction methods is unclear. Here we present a method for absolute quality control of theoretical protein models, which can significantly contribute to their acceptance in the life-science research. We apply these methods to gain insight into the family of hydrophobins and modify them for increased cell adhesion to allow for the coating of implants. The novel proteins were shown to bind cells, while impeding bacterial adhesion.