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High-Throughput Atomistic Modeling of Biomolecular Structure and Association

Strunk, Timo

Abstract:
The reliability of many protein models arising from structure prediction methods is unclear. Here we present a method for absolute quality control of theoretical protein models, which can significantly contribute to their acceptance in the life-science research. We apply these methods to gain insight into the family of hydrophobins and modify them for increased cell adhesion to allow for the coating of implants. The novel proteins were shown to bind cells, while impeding bacterial adhesion.

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Volltext §
DOI: 10.5445/IR/1000036224
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Zugehörige Institution(en) am KIT Institut für Nanotechnologie (INT)
Publikationstyp Hochschulschrift
Jahr 2012
Sprache Englisch
Identifikator urn:nbn:de:swb:90-362248
KITopen-ID: 1000036224
Abschlussart Dissertation
Fakultät Fakultät für Physik (PHYSIK)
Institut Institut für Nanotechnologie (INT)
Prüfungsdaten 02.11.2012
Referent/Betreuer Prof. W. Wenzel
Schlagworte Protein Structure Prediction
KIT – Die Forschungsuniversität in der Helmholtz-Gemeinschaft
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