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High-Throughput Atomistic Modeling of Biomolecular Structure and Association

Strunk, Timo


The reliability of many protein models arising from structure prediction methods is unclear. Here we present a method for absolute quality control of theoretical protein models, which can significantly contribute to their acceptance in the life-science research. We apply these methods to gain insight into the family of hydrophobins and modify them for increased cell adhesion to allow for the coating of implants. The novel proteins were shown to bind cells, while impeding bacterial adhesion.

Volltext §
DOI: 10.5445/IR/1000036224
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Nanotechnologie (INT)
Publikationstyp Hochschulschrift
Publikationsjahr 2012
Sprache Englisch
Identifikator urn:nbn:de:swb:90-362248
KITopen-ID: 1000036224
Verlag Karlsruher Institut für Technologie (KIT)
Art der Arbeit Dissertation
Fakultät Fakultät für Physik (PHYSIK)
Institut Institut für Nanotechnologie (INT)
Prüfungsdaten 02.11.2012
Schlagwörter Protein Structure Prediction
Referent/Betreuer Wenzel, W.
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