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Theoretical and Experimental Investigations of the Interaction of Proteins and Nanoparticles with Biological Membranes

Setzler, Julia Christine


Biomolecular processes related to the interaction of proteins, AuNPs and biological membranes are studied in this thesis. In particular, computational methods were developed, implemented and validated. To characterize the influence of antimicrobial peptides and AuNPs on a membrane, black lipid bilayer experiments were performed. To understand interactions of certain AuNPs with the hERG ion channel, complex formation between these two was studied using atomistic simulations.

Volltext §
DOI: 10.5445/IR/1000042182
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Nanotechnologie (INT)
Publikationstyp Hochschulschrift
Publikationsjahr 2013
Sprache Englisch
Identifikator urn:nbn:de:swb:90-421821
KITopen-ID: 1000042182
HGF-Programm 43.11.03 (POF II, LK 01) Molecular building blocks
Verlag Karlsruher Institut für Technologie (KIT)
Art der Arbeit Dissertation
Fakultät Fakultät für Physik (PHYSIK)
Institut Institut für Nanotechnologie (INT)
Prüfungsdaten 08.11.2013
Prüfungsdatum 08.11.2013
Schlagwörter Gold Nanoparticles, Antimicrobial Peptides, Proteins, Monte Carlo, Black Lipid Bilayer
Referent/Betreuer Wenzel, W.
KIT – Die Forschungsuniversität in der Helmholtz-Gemeinschaft
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