Theoretical and Experimental Investigations of the Interaction of Proteins and Nanoparticles with Biological Membranes
Abstract:
Biomolecular processes related to the interaction of proteins, AuNPs and biological membranes are studied in this thesis. In particular, computational methods were developed, implemented and validated. To characterize the influence of antimicrobial peptides and AuNPs on a membrane, black lipid bilayer experiments were performed. To understand interactions of certain AuNPs with the hERG ion channel, complex formation between these two was studied using atomistic simulations.
| Zugehörige Institution(en) am KIT | Institut für Nanotechnologie (INT) |
| Publikationstyp | Hochschulschrift |
| Publikationsjahr | 2013 |
| Sprache | Englisch |
| Identifikator | urn:nbn:de:swb:90-421821 KITopen-ID: 1000042182 |
| HGF-Programm | 43.11.03 (POF II, LK 01) Molecular building blocks |
| Verlag | Karlsruher Institut für Technologie (KIT) |
| Art der Arbeit | Dissertation |
| Fakultät | Fakultät für Physik (PHYSIK) |
| Institut | Institut für Nanotechnologie (INT) |
| Prüfungsdaten | 08.11.2013 |
| Prüfungsdatum | 08.11.2013 |
| Schlagwörter | Gold Nanoparticles, Antimicrobial Peptides, Proteins, Monte Carlo, Black Lipid Bilayer |
| Referent/Betreuer | Wenzel, W. |