The separation process of particles and liquids in centrifuge is a widely used operation in industry. In spite of the long term usage of centrifuges, the knowledge for a detailed characterization of the interaction of the macroscopic processes due the separation is lacking. Reason for this is the complex multiphase flow and the sediment built-up within the machines. The sediment shape influences the flow behavior. The shape is dependent of the rheological behavior of the sediment. Computational fluid dynamics (CFD) is suitable for the numerical investigation of the complex flow behavior. For consideration of impact of the sediment built-up and rheological behavior on the flow behavior a new low time consumption and in time and place resolved simulation method was invented. The different rheological behavior of suspension and sediment are modelled with separate approaches. Based on an empiric numerical parameter study for the rheological behavior of the sediment the suitable use of the method is approved.