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Computational Insights into Zebrafish Brain Development during Gastrulation

Sinner, Claude

Abstract (englisch):
Computer simulations are advancing to become the third pillar of science besides theory and experiment. In this work, I want to showcase two interdisciplinary projects in which computer simulations greatly enhanced the understanding of novel experimental results. Both of these works cover events during the early developmental stages of zebrafish Danio rerio, (Hamilton, 1822) and elucidate the early stages of brain development. The first work clarifies whether or not a novel short-range transport method via specialized filopodia is able to form the necessary long-range gradient for the hindbrain, midbrain, and forebrain differentiation. The second work employs a cellular Potts model to clarify if a single strongly adhesive progenitor cell group is able to shape the early notochord.

Zugehörige Institution(en) am KIT Institut für Nanotechnologie (INT)
Steinbuch Centre for Computing (SCC)
Publikationstyp Hochschulschrift
Jahr 2017
Sprache Englisch
Identifikator DOI(KIT): 10.5445/IR/1000068105
URN: urn:nbn:de:swb:90-681057
KITopen ID: 1000068105
HGF-Programm 43.21.04; LK 01
Verlag Karlsruhe
Umfang XVI, 118 S.
Abschlussart Dissertation
Fakultät Fakultät für Physik (PHYSIK)
Institut Steinbuch Centre for Computing (SCC)
Prüfungsdatum 03.02.2017
Referent/Betreuer Prof. W. Wenzel
Schlagworte Morphogenesis, Discrete-Event Simulation, Cellular Potts model, Biophysics, Mathematical Biology
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