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Effects of local activation times on the tension development of human cardiomyocytes in a computational model

Müller, A.; Kovacheva, E.; Schuler, S.; Dössel, O.; Baron, L.

Abstract:
The human heart is an organ of high complexity and hence, very challenging to simulate. To calculate the force developed by the human heart and therefore the tension of the muscle fibers, accurate models are necessary. The force generated by the cardiac muscle has physiologically imposed limits and depends on various characteristics such as the length, strain and the contraction velocity of the cardiomyocytes. Another characteristic is the activation time of each cardiomyocyte, which is a wave and not a static value for all cardiomyocytes. To simulate a physiologically correct excitation, the functionality of the cardiac simulation framework CardioMechanics was extended to incorporate inhomogeneous activation times. The functionality was then used to evaluate the effects of local activation times with two different tension models. The active stress generated by the cardiomyocytes was calculated by (i) an explicit function and (ii) an ode-based model. The results of the simulations showed that the maximum pressure in the left ventricle dropped by 2.3% for the DoubleHill model and by 5.3% for the Lumens model. In the right ventricle the simulations showed similar results. ... mehr

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Verlagsausgabe §
DOI: 10.5445/IR/1000090644
Veröffentlicht am 08.02.2019
Coverbild
Zugehörige Institution(en) am KIT Institut für Biomedizinische Technik (IBT)
Publikationstyp Zeitschriftenaufsatz
Jahr 2018
Sprache Englisch
Identifikator ISSN: 2364-5504
urn:nbn:de:swb:90-906440
KITopen-ID: 1000090644
Erschienen in Current directions in biomedical engineering
Band 4
Heft 1
Seiten 247-250
Vorab online veröffentlicht am 22.09.2018
Schlagworte Local activation time, LAT, tension development, active stress, human cardiomyocytes, computational model, whole heart simulation.
Nachgewiesen in Scopus
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