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Long-term exposure to ultrafine particles and incidence of cardiovascular and cerebrovascular disease in the EPIC-NL cohort

Downward, George S.; van Nunen, Erik JHM; Kerckhoffs, Jules; Vineis, Paolo; Brunekreef, Bert; Boer, Jolanda MA; Messier, Kyle P.; Roy, Ananya; Verschuren, W. Monique M.; van der Schouw, Yvonne T.; Sluijs, Ivonne; Gulliver, John; Hoek, Gerard; Vermeulen, Roel

Abstract:
Background: There is a small but growing evidence base that exposure to ultrafine particles (UFP – particles smaller than 100nm) may play an important role in the etiology of several illnesses, including cardiovascular disease (CVD). However, this has been under-explored in population-level studies.

Methods: Using Cox proportional hazard models we studied the association between long-term exposure to UFP (predicted via recently developed land use regression models) and incident cardiovascular disease in the Dutch arm of the European Prospective Investigation into Cancer cohort (EPIC-NL), which contains 33,831 Dutch residents. Hazard ratios (HR) for UFP were compared to HRs for more routinely monitored air pollutants, including PM$_{10}$, PM$_{coarse}$, PM$_{2.5}$, PM$_{2.5}$ absorbance, NO$_{x}$, and NO$_{2}$. Joint-pollutant effects were also evaluated in two-pollutant models.

Results: Long-term exposure to UFP was associated with increased HRs for all incident cardiovascular disease (HR = 1.18 per 10,000 particles/cm$_{3}$, 95% CI: 1.03, 1.34), myocardial infarction (HR = 1.34, 95% CI: 1.00, 1.79), and heart failure (HR = 1.76, 95% CI: 1.17, 2.66). ... mehr

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Volltext §
DOI: 10.5445/IR/1000096842
Veröffentlicht am 25.07.2019
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Zugehörige Institution(en) am KIT Institut für Meteorologie und Klimaforschung - Atmosphärische Aerosolforschung (IMK-AAF)
Publikationstyp Vortrag
Jahr 2019
Sprache Englisch
Identifikator KITopen-ID: 1000096842
Veranstaltung 7th International Symposium on Ultrafine Particles, Air Quality and Climate (2019), Brüssel, Belgien, 15.05.2019 – 16.05.2019
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