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Malic acid production from renewables: A review [in press]

Kövilein, Aline; Kubisch, Christin; Cai, Liyin; Ochsenreither, Katrin

Abstract (englisch):
Malic acid derived from fossil resources is currently applied in the food and beverage industries with a medium global production capacity. However, in the transition from a fossil‐based to a bio‐based economy, biotechnologically produced l‐malic acid may become an important platform chemical with many new applications, especially in the field of biopolymers. In this review, currently used petrochemical production routes to dl‐malic acid are outlined and insights into possible bio‐based alternatives for microbial l‐malic acid production are provided. Besides ecological reasons, the possibility to produce enantiopure l‐malic acid by microbial fermentation is the biggest advantage over chemical synthesis. State‐of‐the‐art and open challenges concerning production host engineering, substrate choice and downstream processing are addressed. With regard to production hosts, a literature overview is given covering the leading natural production strains of Aspergillus, Ustilago and Aureobasidium, as well as Escherichia coli as the most important engineered recombinant host. The utilization of renewable substrates as an alternative to glucose is emphasized in particular as a key aspect for a competitive bio‐based production. ... mehr

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Verlagsausgabe §
DOI: 10.5445/IR/1000104530/pub
Veröffentlicht am 08.01.2020
Postprint §
DOI: 10.5445/IR/1000104530
Frei zugänglich ab 07.11.2020
Originalveröffentlichung
DOI: 10.1002/jctb.6269
Scopus
Zitationen: 1
Web of Science
Zitationen: 1
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Bio- und Lebensmitteltechnik (BLT)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2019
Sprache Englisch
Identifikator ISSN: 0021-8871, 0142-0356, 0268-2575, 0368-4075, 0375-9210, 1097-4660, 1934-998X, 1935-181X
KITopen-ID: 1000104530
Erschienen in Journal of chemical technology & biotechnology
Vorab online veröffentlicht am 06.11.2019
Schlagwörter malic acid, renewable resources, bioprocess, waste stream, industrial organic acid production, bioeconomy
Nachgewiesen in Web of Science
Scopus
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