Organic semiconductors are indispensable for today’s display technologies in the form of organic light-emitting diodes (OLEDs) and further optoelectronic applications. However, organic materials do not reach the same charge carrier mobility as inorganic semiconductors, limiting the efficiency of devices. To find or even design new organic semiconductors with higher charge carrier mobility, computational approaches, in particular multiscale models, are becoming increasingly important. However, such models are computationally very costly, especially when large systems and long timescales are required, which is the case to compute static and dynamic energy disorder, i.e., the dominant factor to determine charge transport. Here, we overcome this drawback by integrating machine learning models into multiscale simulations. This allows us to obtain unprecedented insight into relevant microscopic materials properties, in particular static and dynamic disorder contributions for a series of application-relevant molecules. We find that static disorder and thus the distribution of shallow traps are highly asymmetrical for many materials, impacting widely considered Gaussian disorder models. ... mehrWe furthermore analyze characteristic energy level fluctuation times and compare them to typical hopping rates to evaluate the importance of dynamic disorder for charge transport. We hope that our findings will significantly improve the accuracy of computational methods used to predict application-relevant materials properties of organic semiconductors and thus make these methods applicable for virtual materials design.