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Electro-mechanical whole-heart digital twins: A fully coupled multi-physics approach

Gerach, Tobias ORCID iD icon 1; Schuler, Steffen 1; Fröhlich, Jonathan 2; Lindner, Laura 2; Kovacheva, Ekaterina 1; Moss, Robin; Wülfers, Eike Moritz; Seemann, Gunnar; Wieners, Christian 2; Loewe, Axel ORCID iD icon 1
1 Institut für Biomedizinische Technik (IBT), Karlsruher Institut für Technologie (KIT)
2 Institut für Angewandte und Numerische Mathematik (IANM), Karlsruher Institut für Technologie (KIT)


Mathematical models of the human heart are evolving to become a cornerstone of precision medicine and support clinical decision making by providing a powerful tool to understand the mechanisms underlying pathophysiological conditions. In this study, we present a detailed mathematical description of a fully coupled multi-scale model of the human heart, including electrophysiology, mechanics, and a closed-loop model of circulation. State-of-the-art models based on human physiology are used to describe membrane kinetics, excitation-contraction coupling and active tension generation in the atria and the ventricles. Furthermore, we highlight ways to adapt this framework to patient specific measurements to build digital twins. The validity of the model is demonstrated through simulations on a personalized whole heart geometry based on magnetic resonance imaging data of a healthy volunteer. Additionally, the fully coupled model was employed to evaluate the effects of a typical atrial ablation scar on the cardiovascular system. With this work, we provide an adaptable multi-scale model that allows a comprehensive personalization from ion channels to the organ level enabling digital twin modeling.

Verlagsausgabe §
DOI: 10.5445/IR/1000134275
Veröffentlicht am 23.06.2021
DOI: 10.3390/math9111247
Zitationen: 12
Web of Science
Zitationen: 12
Zitationen: 17
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Biomedizinische Technik (IBT)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2021
Sprache Englisch
Identifikator ISSN: 2227-7390
KITopen-ID: 1000134275
Erschienen in Mathematics
Verlag MDPI
Band 9
Heft 11
Seiten 1247
Bemerkung zur Veröffentlichung Gefördert durch den KIT-Publikationsfonds
Schlagwörter computational modeling; whole heart; electro-mechanic coupling; multi-physics; closed-loop circulation
Nachgewiesen in Dimensions
Web of Science
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