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Dynamic dielectrophoretic cell manipulation is enabled by an innovative electronics platform

Julius, Lourdes Albina Nirupa ORCID iD icon 1; Scheidt, Henrik 1; Krishnan, Gowri 1; Becker, Moritz ORCID iD icon 1; Nassar, Omar 1; Torres-Delgado, Sarai M. 1; Mager, Dario ORCID iD icon 1; Badilita, Vlad 1; Korvink, Jan G. 1
1 Institut für Mikrostrukturtechnik (IMT), Karlsruher Institut für Technologie (KIT)

Abstract:

We report on a portable dielectrophoresis manipulation platform, for the positioning and immobilization of small dielectric objects, such as cells or microbes, using a circular array of up to six symmetrically arranged and independently controllable micro-electrodes. The system’s micro-controller-instructed electronic drivers can be operated in three distinct modes. We demonstrate the system’s function by actuating bacterial cells to specific locations and orientations within a region of interest. Using a deep learning approach, we map voltage phase combinations of the six electrodes to geometrical trap position locations, thereby facilitating smooth trajectory planning.


Verlagsausgabe §
DOI: 10.5445/IR/1000169180
Veröffentlicht am 11.03.2024
Originalveröffentlichung
DOI: 10.1016/j.biosx.2023.100333
Scopus
Zitationen: 4
Dimensions
Zitationen: 4
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Mikrostrukturtechnik (IMT)
Publikationstyp Zeitschriftenaufsatz
Publikationsmonat/-jahr 09.2023
Sprache Englisch
Identifikator ISSN: 2590-1370
KITopen-ID: 1000169180
HGF-Programm 43.35.02 (POF IV, LK 01) Functionality of Soft Matter and Biomolecular Systems
Erschienen in Biosensors and Bioelectronics: X
Verlag Elsevier
Band 14
Seiten Artkl.Nr.: 100333
Nachgewiesen in Dimensions
Scopus
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