Integrated shimming for parallel NMR spectroscopy

This thesis explores the challenges of parallel nuclear magnetic resonance (NMR) spectroscopy, focusing on key technical hurdles. Such hurdles include the need to achieve exceptional B0 homogeneity and efficient inter-detector radiofrequency (RF) signal decoupling. The four-part exploration introduces innovative solutions, ranging from a compact detector system for parallel B0 shimming to a tuned RF detector merging butterfly coil and stripline technologies. Additionally, the thesis explores the combination of parallel NMR with signal amplification by reversible exchange (SABRE) hyperpolarization and addresses obstacles in high-throughput drug development by introducing a novel approach for rapid shimming of parallel detectors. This comprehensive overview provides the background for a detailed examination of each contribution.

Part 1: Parallel NMR Environment for Accelerated Analysis at 1.05 T Field: The first segment addresses the challenges of parallel NMR spectroscopy, proposing a compact detector system featuring two NMR unit cell (NC) resonators. This system successfully implements parallel B0 shimming and RF detection, achieving local field correction within a 1.05 T permanent magnet. ... mehrSignal cross-coupling is significantly suppressed, leading to narrow spectral linewidths (from 400 Hz to 28 Hz) and overcoming spatial inhomogeneity.

Part 2: Compact Tuned Magnetic Resonance Detector: The second part introduces a novel magnetic resonance detector that combines the conductor topology of a butterfly coil with that of a stripline. This design increases the magnetic field intensity B1 per unit current, doubling the detection signal-to-noise ratio (SNR) for mass-limited samples. The detector demonstrates improved RF shielding within an array of similar detectors. It is also compatible with 2D planar manufacturing and surface micromachining.

Part 3: Parallel NMR with Signal Amplification by Reversible Exchange (SABRE) Hy- perpolarization: The third section explores the synergy of parallel NMR with SABRE hyperpolarization, demonstrating the continuous hyperpolarization of two samples through a low-field parallel probehead. This innovative approach enhances the versatility of SABRE hyperpolarization in parallel NMR experiments.

Part 4: Development of Parallel Spectroscopy at 15.2 T Field: The final part focuses on how the technical obstacles that emerged during the low-field experiment was overcome. As a result of our implementation, a new fabrication method for stripline coils is reported, based on an origami technique, that facilitates further up-scaling in the number of detection sites within the magnet bore. An improved linewidth (one is 7 Hz and the other is 4 Hz) was achieved through compact high-order local shimming set. Besides, a deep learning approach is used to rapidly calibrate parallel detectors.