Time-Restricted Eating in Alzheimer’s Disease: TREAD Pilot Trial Design
Racette, Susan B. ; Gunning, Jordan A.; Eagan, Danielle E.; Zaniletti, Isabella; Smith, Tracy L.; DeCuna, Candice J.; Hettiwatte, Yehansa S.; Demeke, Migbare T.; Khan, Nevine A.; Aliskevich, Emily L.; Krell-Rösch, Janina
1; Geda, Yonas E.
1 Institut für Sport und Sportwissenschaft (IfSS), Karlsruher Institut für Technologie (KIT)
1; Geda, Yonas E.1 Institut für Sport und Sportwissenschaft (IfSS), Karlsruher Institut für Technologie (KIT)
Abstract:
Background and objective
Time-restricted eating (TRE) may slow neurodegeneration and cognitive decline by stimulating metabolic processes that are neuroprotective. The primary aim of the TRE in Alzheimer’s Disease (TREAD) pilot trial is to evaluate the feasibility of implementing a TRE intervention among individuals with mild cognitive impairment (MCI) and to obtain preliminary data on cognitive domains and blood biomarkers that are responsive to TRE.
Methods
TREAD is an intervention trial for 30 adults aged 55-89 years with MCI. A pre/post design is used, with neuropsychological assessments, surveys, and blood biomarkers of cardiometabolic health and AD obtained before and after the intervention. The TRE intervention involves 16h of continuous fasting and an 8h eating window on 5 or more days per week for 12 weeks. Feasibility measures include participant enrollment, retention, adherence, acceptability of the intervention, and safety. Cognitive measures include executive function, working memory, processing speed, auditory attention, auditory verbal learning, visuospatial memory, category fluency, and phonemic fluency.
Summary
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Time-restricted eating (TRE) may slow neurodegeneration and cognitive decline by stimulating metabolic processes that are neuroprotective. The primary aim of the TRE in Alzheimer’s Disease (TREAD) pilot trial is to evaluate the feasibility of implementing a TRE intervention among individuals with mild cognitive impairment (MCI) and to obtain preliminary data on cognitive domains and blood biomarkers that are responsive to TRE.
Methods
TREAD is an intervention trial for 30 adults aged 55-89 years with MCI. A pre/post design is used, with neuropsychological assessments, surveys, and blood biomarkers of cardiometabolic health and AD obtained before and after the intervention. The TRE intervention involves 16h of continuous fasting and an 8h eating window on 5 or more days per week for 12 weeks. Feasibility measures include participant enrollment, retention, adherence, acceptability of the intervention, and safety. Cognitive measures include executive function, working memory, processing speed, auditory attention, auditory verbal learning, visuospatial memory, category fluency, and phonemic fluency.
Summary
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| Zugehörige Institution(en) am KIT | Institut für Sport und Sportwissenschaft (IfSS) |
| Publikationstyp | Zeitschriftenaufsatz |
| Publikationsmonat/-jahr | 12.2025 |
| Sprache | Englisch |
| Identifikator | ISSN: 2451-8654 KITopen-ID: 1000186191 |
| Erschienen in | Contemporary clinical trials communications |
| Verlag | Elsevier |
| Band | 48 |
| Seiten | 101564 |
| Bemerkung zur Veröffentlichung | in press |
| Schlagwörter | Time-restricted eating; Alzheimer’s disease; mild cognitive impairment |
| Nachgewiesen in | Dimensions OpenAlex Scopus |
| Globale Ziele für nachhaltige Entwicklung |