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Control of steroid receptor dynamics and function by genomic actions of the cochaperones p23 and Bag-1L

Cato, L.; Neeb, A.; Brown, M.; Cato, A.C.B.

Molecular chaperones encompass a group of unrelated proteins that facilitate the correct assembly and disassembly of other macromolecular structures of which they themselves do not remain a part. Chaperones associate with a large and diverse set of cofactors termed cochaperones that regulate their function and specificity. Chaperones and cochaperones regulate the activity of several classes of signaling molecules, including steroid receptors. Upon binding ligand, steroid receptors interact with discrete nucleotide sequences within the nucleus to control the expression of diverse physiological and developmental genes. Molecular chaperones and cochaperones are typically known to provide the correct conformation for ligand binding by the steroid receptors. While this contribution is widely accepted, recent studies have reported that they further modulate steroid receptor action outside ligand binding. Specifically, they are thought to contribute to receptor turnover, transport of the receptor to different subcellular localizations, recycling of the receptor on chromatin and stabilization of receptor DNA binding. In addition to these combined effects with molecular chaperones, cochaperones have additional functions that are independent of molecular chaperones, some of which impact steroid receptor action. ... mehr

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Verlagsausgabe §
DOI: 10.5445/IR/120098120
Veröffentlicht am 29.10.2018
DOI: 10.1621/nrs.12005
Zitationen: 8
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Toxikologie und Genetik (ITG)
Publikationstyp Zeitschriftenaufsatz
Publikationsjahr 2014
Sprache Englisch
Identifikator ISSN: 1550-7629
KITopen-ID: 120098120
HGF-Programm 47.02.01 (POF II, LK 01) Synth. biomimetische Werkzeuge ITG
Erschienen in Nuclear receptor signaling
Verlag SAGE Publications
Band 12
Seiten e005/1-15
Schlagwörter Steroid receptors; nuclear receptors, chaperones, cellular transport
Nachgewiesen in Scopus
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