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Advancing process development for antibody-drug conjugates - Incorporation of high-throughput, analytical, and digital tools

Andris, Sebastian

Abstract (englisch):
Antibody-drug conjugates (ADCs) have been designed as a combination of monoclonal antibody (mAb) therapy and chemotherapy. From this fact, they draw their potential of uniting the advantages of both strategies in one molecule. mAbs have the ability to specifically bind their target antigen, thus focusing the effect on the target site of action. Due to their size and other biochemical properties, they have a good circulation half-life in the body, which is an important pharmacokinetic property. While mAbs are applied in various therapeutic fields, they form a highly important part of modern oncology. Here, mAbs are used to target antigens that are highly expressed on cancer cells, exhibiting different modes of action to fight the cancer. In order to increase their capacity of killing cancer cells, small cytotoxic molecules, as applied in chemotherapy, can be covalently attached to the mAbs, forming ADCs. Due to the decreased systemic exposure, drug molecules with higher cytotoxicity can be used. Motivated by this potential and the market approval of the first successful products in 2011 and 2013, ADCs gained a lot of attention. By the end of 2019, there were already six products on the market and over 60 candidates in clinical trials. ... mehr

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Volltext §
DOI: 10.5445/IR/1000120055
Veröffentlicht am 10.06.2020
Cover der Publikation
Zugehörige Institution(en) am KIT Institut für Bio- und Lebensmitteltechnik (BLT)
Publikationstyp Hochschulschrift
Publikationsdatum 10.06.2020
Sprache Englisch
Identifikator KITopen-ID: 1000120055
Verlag Karlsruhe
Umfang XV, 140 S.
Art der Arbeit Dissertation
Fakultät Fakultät für Chemieingenieurwesen und Verfahrenstechnik (CIW)
Institut Institut für Bio- und Lebensmitteltechnik (BLT)
Prüfungsdatum 14.05.2020
Referent/Betreuer Prof. J. Hubbuch
Schlagwörter Antibody-drug conjugates, process development, protein conjugation, monoclonal antibody, high-throughput experimentation, process analytical technology (PAT), kinetic model, chromatography model
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